Relative immunogenicity of the cold-adapted influenza virus A/Ann Arbor/6/60 (A/AA/6/60-ca), recombinants of A/AA/6/60-ca, and parental strains with similar surface antigens.
Identifieur interne : 002488 ( Main/Exploration ); précédent : 002487; suivant : 002489Relative immunogenicity of the cold-adapted influenza virus A/Ann Arbor/6/60 (A/AA/6/60-ca), recombinants of A/AA/6/60-ca, and parental strains with similar surface antigens.
Auteurs : G A Tannock ; J A Paul ; R D BarrySource :
- Infection and immunity [ 0019-9567 ] ; 1984.
Descripteurs français
- KwdFr :
- MESH :
- analyse : Antigènes de surface, Antigènes viraux.
- génétique : Virus de la grippe A.
- immunologie : Vaccins antigrippaux, Virus de la grippe A.
- microbiologie : Poumon.
- Animaux, Basse température, Recombinaison génétique, Réplication virale, Souris.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Antigens, Surface, Antigens, Viral.
- drug effects : Virus Replication.
- genetics : Influenza A virus.
- immunology : Influenza A virus, Influenza Vaccines.
- microbiology : Lung.
- Animals, Cold Temperature, Mice, Recombination, Genetic.
Abstract
The immunogenicity of several cold-adapted (ca) viruses was compared in CSL mice with that of wild-type parental viruses with similar surface antigens, according to the vaccinating dose required to clear a challenge consisting of 10(4.5) 50% tissue culture infective doses of the wild-type virus. All ca viruses were less immunogenic than their wild-type parental strains by a factor of 10(1.3) to 10(3.4), probably due to the restricted capacity of ca viruses to replicate in the respiratory tracts of mice. However, their immunogenicity was considerably enhanced when two quite small doses were administered 3 weeks apart. The immunogenicity of ca viruses when administered in two doses and wild-type viruses when administered as a single dose varied according to their surface antigens. It was highest for viruses with the H2N2 A/Ann Arbor/6/60 and H3N2 A/Queensland/6/72 surface antigens and lowest for those with H1N1 A/HK/123/77 surface antigens. When two doses consisting of 10(5.0) 50% tissue culture infective doses of A/Ann Arbor/6/60-ca were administered at an interval of 3 weeks, solid immunity was induced against the wild-type A/Ann Arbor/6/60 parental virus, two heterologous H3N2 strains, and an H1N1 strain.
PubMed: 6693167
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000524
- to stream PubMed, to step Curation: 000524
- to stream PubMed, to step Checkpoint: 000459
- to stream Ncbi, to step Merge: 001214
- to stream Ncbi, to step Curation: 001214
- to stream Ncbi, to step Checkpoint: 001214
- to stream Main, to step Merge: 002612
- to stream Main, to step Curation: 002488
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Relative immunogenicity of the cold-adapted influenza virus A/Ann Arbor/6/60 (A/AA/6/60-ca), recombinants of A/AA/6/60-ca, and parental strains with similar surface antigens.</title><author><name sortKey="Tannock, G A" sort="Tannock, G A" uniqKey="Tannock G" first="G A" last="Tannock">G A Tannock</name></author><author><name sortKey="Paul, J A" sort="Paul, J A" uniqKey="Paul J" first="J A" last="Paul">J A Paul</name></author><author><name sortKey="Barry, R D" sort="Barry, R D" uniqKey="Barry R" first="R D" last="Barry">R D Barry</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1984">1984</date><idno type="RBID">pubmed:6693167</idno><idno type="pmid">6693167</idno><idno type="wicri:Area/PubMed/Corpus">000524</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000524</idno><idno type="wicri:Area/PubMed/Curation">000524</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000524</idno><idno type="wicri:Area/PubMed/Checkpoint">000459</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000459</idno><idno type="wicri:Area/Ncbi/Merge">001214</idno><idno type="wicri:Area/Ncbi/Curation">001214</idno><idno type="wicri:Area/Ncbi/Checkpoint">001214</idno><idno type="wicri:doubleKey">0019-9567:1984:Tannock G:relative:immunogenicity:of</idno><idno type="wicri:Area/Main/Merge">002612</idno><idno type="wicri:Area/Main/Curation">002488</idno><idno type="wicri:Area/Main/Exploration">002488</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Relative immunogenicity of the cold-adapted influenza virus A/Ann Arbor/6/60 (A/AA/6/60-ca), recombinants of A/AA/6/60-ca, and parental strains with similar surface antigens.</title><author><name sortKey="Tannock, G A" sort="Tannock, G A" uniqKey="Tannock G" first="G A" last="Tannock">G A Tannock</name></author><author><name sortKey="Paul, J A" sort="Paul, J A" uniqKey="Paul J" first="J A" last="Paul">J A Paul</name></author><author><name sortKey="Barry, R D" sort="Barry, R D" uniqKey="Barry R" first="R D" last="Barry">R D Barry</name></author></analytic><series><title level="j">Infection and immunity</title><idno type="ISSN">0019-9567</idno><imprint><date when="1984" type="published">1984</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigens, Surface (analysis)</term><term>Antigens, Viral (analysis)</term><term>Cold Temperature</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (immunology)</term><term>Influenza Vaccines (immunology)</term><term>Lung (microbiology)</term><term>Mice</term><term>Recombination, Genetic</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antigènes de surface (analyse)</term><term>Antigènes viraux (analyse)</term><term>Basse température</term><term>Poumon (microbiologie)</term><term>Recombinaison génétique</term><term>Réplication virale ()</term><term>Souris</term><term>Vaccins antigrippaux (immunologie)</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigens, Surface</term><term>Antigens, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigènes de surface</term><term>Antigènes viraux</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cold Temperature</term><term>Mice</term><term>Recombination, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Basse température</term><term>Recombinaison génétique</term><term>Réplication virale</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The immunogenicity of several cold-adapted (ca) viruses was compared in CSL mice with that of wild-type parental viruses with similar surface antigens, according to the vaccinating dose required to clear a challenge consisting of 10(4.5) 50% tissue culture infective doses of the wild-type virus. All ca viruses were less immunogenic than their wild-type parental strains by a factor of 10(1.3) to 10(3.4), probably due to the restricted capacity of ca viruses to replicate in the respiratory tracts of mice. However, their immunogenicity was considerably enhanced when two quite small doses were administered 3 weeks apart. The immunogenicity of ca viruses when administered in two doses and wild-type viruses when administered as a single dose varied according to their surface antigens. It was highest for viruses with the H2N2 A/Ann Arbor/6/60 and H3N2 A/Queensland/6/72 surface antigens and lowest for those with H1N1 A/HK/123/77 surface antigens. When two doses consisting of 10(5.0) 50% tissue culture infective doses of A/Ann Arbor/6/60-ca were administered at an interval of 3 weeks, solid immunity was induced against the wild-type A/Ann Arbor/6/60 parental virus, two heterologous H3N2 strains, and an H1N1 strain.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Barry, R D" sort="Barry, R D" uniqKey="Barry R" first="R D" last="Barry">R D Barry</name><name sortKey="Paul, J A" sort="Paul, J A" uniqKey="Paul J" first="J A" last="Paul">J A Paul</name><name sortKey="Tannock, G A" sort="Tannock, G A" uniqKey="Tannock G" first="G A" last="Tannock">G A Tannock</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002488 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002488 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:6693167
|texte= Relative immunogenicity of the cold-adapted influenza virus A/Ann Arbor/6/60 (A/AA/6/60-ca), recombinants of A/AA/6/60-ca, and parental strains with similar surface antigens.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:6693167" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |